Volunteers who received CBD, diazepam (Valium), and isapirone all showed a decrease in anxiety and systolic blood pressure.
Volunteers who got the diazepam (Valium) experienced feeling physical sedation.
Volunteers who got CBD and isapirone did not experience physical sedation, mental sedation, or other negative side effects.
So, taking CBD oil a few minutes before you speak or present can help calm your brain and ensure fear isn’t in control of your mind. This is thought to be because cannabidiol elevates an endocannabinoid called anandamide which helps reduce the overactivity in your brain causing the anxiety.
When we break that process down, it goes like this: Anandamide works through a process called retrograde signalling. It travels backward from the receiving cell to the sending cell with its own type of message. This message is telling the sending cell to either stop sending so many signals, or to send more because there isn’t enough activity. With anxiety, anandamide tells the sending cell to calm down, so your receiving cell doesn’t get overwhelmed.